Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1PL7M)

• DTT Name: E-selectin messenger RNA (SELE mRNA)
• Synonyms: Leukocyte-endothelial cell adhesion molecule 2 (mRNA); LECAM2 (mRNA); Endothelial leukocyte adhesion molecule 1 (mRNA); ELAM1 (mRNA); ELAM-1 (mRNA); E-selectin (mRNA); CD62E antigen (mRNA); CD62E (mRNA); CD62 antigen-like family member E (mRNA)
• Gene Name: SELE
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: LYAM2_HUMAN
• TTD ID: T87916
• Sequence:
  MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLN
  SILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREK
  DVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNC
  TALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVV
  ECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCK
  AVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIP
  VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN
  EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ
  WTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHW
  SGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESD
  GSYQKPSYIL
• Function: Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. Cell-surface glycoprotein having a role in immunoadhesion.
• KEGG Pathway:
  Cell adhesion molecules (CAMs) (hsa04514)
  TNF signaling pathway (hsa04668)
  African trypanosomiasis (hsa05143)
  Malaria (hsa05144)
• Reactome Pathway: Cell surface interactions at the vascular wall (R-HSA-202733)

Molecular Interaction Atlas (MIA) of This DTT

11 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 11929	DMZYOPD	Discovery agent	N.A.	Investigative	[1]
ISIS 2674	DMRUEM8	Discovery agent	N.A.	Investigative	[2]
ISIS 2678	DMZP5VG	Discovery agent	N.A.	Investigative	[2]
ISIS 2686	DM78BDU	Discovery agent	N.A.	Investigative	[2]
ISIS 4719	DMXNBGP	Discovery agent	N.A.	Investigative	[2]
ISIS 4729	DMD67YO	Discovery agent	N.A.	Investigative	[2]
ISIS 4730	DMKU1PN	Discovery agent	N.A.	Investigative	[2]
ISIS 4756	DMCZK1U	Discovery agent	N.A.	Investigative	[2]
ISIS 4759	DM3PZUX	Discovery agent	N.A.	Investigative	[2]
ISIS 4764	DMLA5I9	Discovery agent	N.A.	Investigative	[1]
ISIS 9984	DM054SL	Discovery agent	N.A.	Investigative	[1]

References

• [1] US patent application no. 5,789,573, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2.
• [2] US patent application no. 5,843,738, Oligonucleotide modulation of cell adhesion.