Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1R5DZ)

DTT Name	Rho guanine nucleotide exchange factor 3 (ARHGEF3)
Synonyms	XPLN; Exchange factor found in platelets and leukemic and neuronal tissues
Gene Name	ARHGEF3
DTT Type	Literature-reported target	[1]
UniProt ID	ARHG3_HUMAN
TTD ID	T96393
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPL KRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKE IKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEEL LSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQR CLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAE INTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVI TRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKN GSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGE TKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV
Function	Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
Reactome Pathway	G alpha (12/13) signalling events (R-HSA-416482 ) RHOA GTPase cycle (R-HSA-8980692 ) RHOB GTPase cycle (R-HSA-9013026 ) NRAGE signals death through JNK (R-HSA-193648 )

References

1	XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts. Pulm Pharmacol Ther. 2017 Jun;44:61-69.