Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1S4LJ)

• DTT Name: RRM2 messenger RNA (RRM2 mRNA)
• Synonyms: Ribonucleotide reductase small subunit (mRNA); Ribonucleotide reductase small chain (mRNA); Ribonucleoside-diphosphate reductase subunit M2 (mRNA); RR2 (mRNA)
• Gene Name: RRM2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: mRNA target
• UniProt ID: RIR2_HUMAN
• TTD ID: T54779
• EC Number: EC 1.17.4.1
• Sequence:
  MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
  KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
  PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
  DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
  ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
  QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
  FFEKRVGEYQRMGVMSSPTENSFTLDADF
• Function: Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Provides the precursors necessary for DNA synthesis.
• KEGG Pathway:
  Purine metabolism (hsa00230)
  Pyrimidine metabolism (hsa00240)
  Glutathione metabolism (hsa00480)
  Metabolic pathways (hsa01100)
  p53 signaling pathway (hsa04115)
• Reactome Pathway:
  G1/S-Specific Transcription (R-HSA-69205)
  E2F mediated regulation of DNA replication (R-HSA-113510)
• BioCyc Pathway: MetaCyc:HS10398-MON

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Gastric cancer	2C82	Gastric tissue	1.51E-01	3.56	1.71

References

• [1] NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.