Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1UZQH)

DTT Name Phospholipase C (PLC)
Gene Name PLC
DTT Type
Clinical trial target
 [1]
BioChemical Class
Phosphoric diester hydrolase
UniProt ID
NOUNIPROTAC
TTD ID
T77534

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
D-20133 DMTP9ER Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
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1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phosphonate DMAJ9ZD leukaemia 2A60-2B33 Terminated [2]
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References

1 Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain. Curr Med Chem. 2011; 18(18): 2727-2742.
2 Inhibition of phosphatidylinositol-specific phospholipase C by phosphonate substrate analogues. Biochim Biophys Acta. 1990 Feb 23;1042(3):410-2.