Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT21AKM)

DTT Name	Corticotropin-lipotropin (POMC)
Synonyms	Pro-opiomelanocortin
Gene Name	POMC
DTT Type	Literature-reported target	[1]
UniProt ID	COLI_HUMAN
TTD ID	T62912
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF MTSEKSQTPLVTLFKNAIIKNAYKKGE
Function	Corticotropin: Stimulates the adrenal glands to release cortisol.
KEGG Pathway	Melanogenesis (hsa04916 ) Adipocytokine signaling pathway (hsa04920 )
Reactome Pathway	Glucocorticoid biosynthesis (R-HSA-194002 ) Endogenous sterols (R-HSA-211976 ) Peptide ligand-binding receptors (R-HSA-375276 ) G alpha (s) signalling events (R-HSA-418555 ) G alpha (i) signalling events (R-HSA-418594 ) Androgen biosynthesis (R-HSA-193048 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydromorphine	DM4TR0D	Discovery agent	N.A.	Investigative	[1]
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References

1	Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5.