Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT25MVL)

• DTT Name: Serine protease hepsin (HPN)
• Synonyms: Transmembrane protease, serine 1; HPN; HEPSIN
• Gene Name: HPN
• DTT Type: Patented-recorded target; [1]
• BioChemical Class: Peptidase
• UniProt ID: HEPS_HUMAN
• TTD ID: T73471
• EC Number: EC 3.4.21.106
• Sequence:
  MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
  ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
  DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
  RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
  GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
  YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
  DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
• Function: Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.
• KEGG Pathway: Viral carcinogenesis (hsa05203)
• Reactome Pathway:
  Signaling by MST1 (R-HSA-8852405)
  MET Receptor Activation (R-HSA-6806942)

Molecular Interaction Atlas (MIA) of This DTT

1 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AC1LFXA6	DMEVBZW	N. A.	N. A.	Patented	[2]

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylsulfinic Acid	DM7XK28	Discovery agent	N.A.	Investigative	[1]
CRA_1144	DMK54RM	Discovery agent	N.A.	Investigative	[1]

References

• [1] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [2] Hepsin inhibitors. US9182402.