Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT283NK)

DTT Name	Bacterial NADH-dependent enoyl-ACP reductase 2 (Bact fabI2)
Synonyms	NADH-dependent enoyl-ACP reductase 2; Enoyl-[acyl-carrier-protein] reductase [NADH] 2
Gene Name	Bact fabI2
DTT Type	Literature-reported target	[1]
BioChemical Class	CH-CH donor oxidoreductase
UniProt ID	FABI2_RHIME
TTD ID	T79589
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MNGLMNGKRGLIMGVANSHSIAWGIAKSLAAQGAELAFTYQGEALGKRVKPLAAEVNSDF LLPCDVEDIGSVDAVVDAIKERWGKLDFVVHAIGFSDKNELKGLYADTTRDNFSRTMVIS CFSFTEIAKRAAELMSEGGTMLTLTYGGSMRVMPNYNVMGVAKAALEASVRYLAADYGSR GIRVNAISAGPIRTLAGAGISDARAMLSWQQKNSPLRRTVTIEDVGSSALYLLSDLSRGV TGEIHYVDSGYNITSMPTLEALRVADAD
Function	Identified as the FabI protein, which is the target of a group of antibacterial compounds, the diazaborines.
KEGG Pathway	Fatty acid biosynthesis (sme00061 ) Biotin metabolism (sme00780 ) Metabolic pathways (sme01100 ) Fatty acid metabolism (sme01212 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[1]
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References

1	Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.