Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT2IS7P)

• DTT Name: Divalent metal transporter 1 (SLC11A2)
• Synonyms: Solute carrier family 11 member 2; OK/SW-cl.20; Natural resistanceassociated macrophage protein 2; Natural resistance-associated macrophage protein 2; NRAMP2; NRAMP 2; Divalent cation transporter 1; DMT1; DMT-1; DCT1
• Gene Name: SLC11A2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Natural resistance-associated macrophage protein
• UniProt ID: NRAM2_HUMAN
• TTD ID: T22717
• Sequence:
  MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE
  EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR
  LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI
  PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM
  FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES
  CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG
  VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI
  IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG
  GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC
  GHTCHLGLTAQPELYLLNTMDADSLVSR
• Function: Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. Important in metal transport, in particular iron.
• KEGG Pathway:
  Lysosome (hsa04142)
  Ferroptosis (hsa04216)
  Mineral absorption (hsa04978)
  Alzheimer disease (hsa05010)
  Parkinson disease (hsa05012)
• Reactome Pathway:
  Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) (R-HSA-5619048)
  Iron uptake and transport (R-HSA-917937)
  Metal ion SLC transporters (R-HSA-425410)

The Drug Transporter (DTP) Role of This DTT

• DTT DTP Name: Natural resistance-associated macrophage protein 2 (SLC11A2) DTP Info
• Gene Name: SLC11A2

1 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Iron	DMAP8MV	Anemia of prematurity		Approved	[2]

1 Investigative Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Manganese	DMKT129	N. A.	N. A.	Investigative	[2]

References

• [1] Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18578-83.
• [2] Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 2009 Sep 8;48(35):8422-34.