Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT2LHI6)

DTT Name	GPI transamidase component PIG-U (PIGU)
Synonyms	UNQ3055/PRO9875; Phosphatidylinositol-glycan biosynthesis, class U protein; PIGU; PIG-U; Cell division cycle protein 91-like 1; CDC91L1; CDC91-like 1 protein
Gene Name	PIGU
DTT Type	Literature-reported target	[1]
UniProt ID	PIGU_HUMAN
TTD ID	T00088
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSG AVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYA PDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAF LSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVI ICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFY TIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTC IIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQILLISDYFYAFLRREYYLTHGL YLTAKDGTEAMLVLK
Function	Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
KEGG Pathway	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis (hsa00563 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Attachment of GPI anchor to uPAR (R-HSA-162791 )

References

1	CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer. Nat Med. 2004 Apr;10(4):374-81.