DTT Name |
EGFR Exon20ins mutant (EGFR Exon20ins)
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Gene Name |
EGFR
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DTT Type |
Clinical trial target
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[1] |
UniProt ID |
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TTD ID |
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3D Structure |
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Sequence |
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV APQSSEFIGA
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KEGG Pathway |
- EGFR tyrosine kinase inhibitor resistance (hsa01521 )
- Endocrine resistance (hsa01522 )
- MAPK signaling pathway (hsa04010 )
- ErbB signaling pathway (hsa04012 )
- Ras signaling pathway (hsa04014 )
- Rap1 signaling pathway (hsa04015 )
- Calcium signaling pathway (hsa04020 )
- HIF-1 signaling pathway (hsa04066 )
- FoxO signaling pathway (hsa04068 )
- Phospholipase D signaling pathway (hsa04072 )
- Endocytosis (hsa04144 )
- PI3K-Akt signaling pathway (hsa04151 )
- Focal adhesion (hsa04510 )
- Adherens junction (hsa04520 )
- Gap junction (hsa04540 )
- JAK-STAT signaling pathway (hsa04630 )
- Regulation of actin cytoskeleton (hsa04810 )
- GnRH signaling pathway (hsa04912 )
- Estrogen signaling pathway (hsa04915 )
- Oxytocin signaling pathway (hsa04921 )
- Relaxin signaling pathway (hsa04926 )
- Parathyroid hormone synthesis, secretion and action (hsa04928 )
- Cushing syndrome (hsa04934 )
- Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
- Shigellosis (hsa05131 )
- Hepatitis C (hsa05160 )
- Human cytomegalovirus infection (hsa05163 )
- Human papillomavirus infection (hsa05165 )
- Coronavirus disease - COVID-19 (hsa05171 )
- Pathways in cancer (hsa05200 )
- Proteoglycans in cancer (hsa05205 )
- MicroRNAs in cancer (hsa05206 )
- Chemical carcinogenesis - receptor activation (hsa05207 )
- Chemical carcinogenesis - reactive oxygen species (hsa05208 )
- Colorectal cancer (hsa05210 )
- Pancreatic cancer (hsa05212 )
- Endometrial cancer (hsa05213 )
- Glioma (hsa05214 )
- Prostate cancer (hsa05215 )
- Melanoma (hsa05218 )
- Bladder cancer (hsa05219 )
- Non-small cell lung cancer (hsa05223 )
- Breast cancer (hsa05224 )
- Hepatocellular carcinoma (hsa05225 )
- Gastric cancer (hsa05226 )
- Central carbon metabolism in cancer (hsa05230 )
- Choline metabolism in cancer (hsa05231 )
- PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
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Reactome Pathway |
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382 )
- Signaling by ERBB4 (R-HSA-1236394 )
- SHC1 events in ERBB2 signaling (R-HSA-1250196 )
- PLCG1 events in ERBB2 signaling (R-HSA-1251932 )
- PIP3 activates AKT signaling (R-HSA-1257604 )
- Signaling by EGFR (R-HSA-177929 )
- GRB2 events in EGFR signaling (R-HSA-179812 )
- GAB1 signalosome (R-HSA-180292 )
- SHC1 events in EGFR signaling (R-HSA-180336 )
- EGFR downregulation (R-HSA-182971 )
- GRB2 events in ERBB2 signaling (R-HSA-1963640 )
- PI3K events in ERBB2 signaling (R-HSA-1963642 )
- EGFR interacts with phospholipase C-gamma (R-HSA-212718 )
- EGFR Transactivation by Gastrin (R-HSA-2179392 )
- Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530 )
- Signal transduction by L1 (R-HSA-445144 )
- Constitutive Signaling by EGFRvIII (R-HSA-5637810 )
- Inhibition of Signaling by Overexpressed EGFR (R-HSA-5638303 )
- RAF/MAP kinase cascade (R-HSA-5673001 )
- ERBB2 Regulates Cell Motility (R-HSA-6785631 )
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (R-HSA-6811558 )
- ERBB2 Activates PTK6 Signaling (R-HSA-8847993 )
- Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825 )
- Clathrin-mediated endocytosis (R-HSA-8856828 )
- PTK6 promotes HIF1A stabilization (R-HSA-8857538 )
- Downregulation of ERBB2 signaling (R-HSA-8863795 )
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (R-HSA-8866910 )
- Extra-nuclear estrogen signaling (R-HSA-9009391 )
- NOTCH3 Activation and Transmission of Signal to the Nucleus (R-HSA-9013507 )
- HCMV Early Events (R-HSA-9609690 )
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling (R-HSA-9634638 )
- Signaling by ERBB2 KD Mutants (R-HSA-9664565 )
- Signaling by ERBB2 ECD mutants (R-HSA-9665348 )
- Signaling by ERBB2 TMD/JMD mutants (R-HSA-9665686 )
- Signaling by ERBB2 (R-HSA-1227986 )
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