Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TT2ZUPY)
| DTT Name | Prostate derived ETS factor (SPDEF) | ||||
|---|---|---|---|---|---|
| Synonyms | SAM pointed domain-containing Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor; Prostate epithelium-specific Ets transcription factor; PSE; PDEF | ||||
| Gene Name | SPDEF | ||||
| DTT Type |
Literature-reported target
|
[1] | |||
| BioChemical Class |
E26 transformation-specific ETS
|
||||
| UniProt ID | |||||
| TTD ID | |||||
| 3D Structure | |||||
| Sequence |
MGSASPGLSSVSPSHLLLPPDTVSRTGLEKAAAGAVGLERRDWSPSPPATPEQGLSAFYL
SYFDMLYPEDSSWAAKAPGASSREEPPEEPEQCPVIDSQAPAGSLDLVPGGLTLEEHSLE QVQSMVVGEVLKDIETACKLLNITADPMDWSPSNVQKWLLWTEHQYRLPPMGKAFQELAG KELCAMSEEQFRQRSPLGGDVLHAHLDIWKSAAWMKERTSPGAIHYCASTSEESWTDSEV DSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKNRPAM NYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPI |
||||
| Function |
Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter.
|
||||