Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT38ECI)

DTT Name Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK)
Synonyms PPPK; HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gene Name Bact folK
DTT Type
Literature-reported target
 [1]
Related Disease
Schizophrenia [ICD-11: 6A20]
BioChemical Class
Kinase
UniProt ID
HPPK_ECOLI
TTD ID
T79724
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVA
LETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMK
NRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
Function 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity, magnesium ion binding
KEGG Pathway
Folate biosynthesis (ecj00790 )
Metabolic pathways (ecj01100 )
Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway
MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-MON
EcoCyc:H2PTERIDINEPYROPHOSPHOKIN-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Preclinical Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PD-157695 DMDSR1X Schizophrenia 6A20 Preclinical [1]
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6 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
6-Hydroxymethyl-7,8-Dihydropterin DMYF60K Discovery agent N.A. Investigative [2]
6-Hydroxymethylpterin DM7EWDN Discovery agent N.A. Investigative [3]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [2]
P(1)-(6-Hydroxymethylpterin)-P(4)-(5'-adenosyl)tetraphosphate DMOY627 Discovery agent N.A. Investigative [1]
[3H]alphabeta-meATP DMWV5C3 Discovery agent N.A. Investigative [2]
[Pterin-6-Yl Methanyl]-Phosphonophosphate DM4ZY79 Discovery agent N.A. Investigative [2]
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⏷ Show the Full List of 6 Investigative Drug(s)

References

1 Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.