Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT3JF9E)

• DTT Name: Keratin type I cytoskeletal 19 (KRT19)
• Synonyms: Keratin19; Keratin, type I cytoskeletal 19; KRT19; K19; Cytokeratin19; CK19
• Gene Name: KRT19
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Intermediate filament family
• UniProt ID: K1C19_HUMAN
• TTD ID: T54461
• Sequence:
  MTSYSYRQSSATSSFGGLGGGSVRFGPGVAFRAPSIHGGSGGRGVSVSSARFVSSSSSGA
  YGGGYGGVLTASDGLLAGNEKLTMQNLNDRLASYLDKVRALEAANGELEVKIRDWYQKQG
  PGPSRDYSHYYTTIQDLRDKILGATIENSRIVLQIDNARLAADDFRTKFETEQALRMSVE
  ADINGLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTLRGQVGGQVSVEVDSA
  PGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVAGHTEQLQMSRSEVTDLR
  RTLQGLEIELQSQLSMKAALEDTLAETEARFGAQLAHIQALISGIEAQLGDVRADSERQN
  QEYQRLMDIKSRLEQEIATYRSLLEGQEDHYNNLSASKVL
• Function: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}.
• KEGG Pathway:
  Estrogen signaling pathway (hsa04915)
  Staphylococcus aureus infection (hsa05150)
• Reactome Pathway:
  Formation of the cornified envelope (R-HSA-6809371)
  Keratinization (R-HSA-6805567)

References

• [1] Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma. Clin Cancer Res. 2015 Jul 1;21(13):3081-91.