Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT3K9S2)

DTT Name RANK messenger RNA (RANK mRNA)
Synonyms Tumor necrosis factor receptor superfamily member 11A (mRNA); Receptor activator of NF-KB (mRNA); RANK (mRNA); Osteoclast differentiation factor receptor (mRNA); ODFR (mRNA); CD265 (mRNA)
Gene Name TNFRSF11A
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
TNR11_HUMAN
TTD ID
T24800
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPRARRRRPLFALLLLCALLARLQVALQIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKC
TTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHW
SQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGK
RVEHHGTEKSDAVCSSSLPARKPPNEPHVYLPGLIILLLFASVALVAAIIFGVCYRKKGK
ALTANLWHWINEACGRLSGDKESSGDSCVSTHTANFGQQGACEGVLLLTLEEKTFPEDMC
YPDQGGVCQGTCVGGGPYAQGEDARMLSLVSKTEIEEDSFRQMPTEDEYMDRPSQPTDQL
LFLTEPGSKSTPPFSEPLEVGENDSLSQCFTGTQSTVGSESCNCTEPLCRTDWTPMSSEN
YLQKEVDSGHCPHWAASPSPNWADVCTGCRNPPGEDCEPLVGSPKRGPLPQCAYGMGLPP
EEEASRTEARDQPEDGADGRLPSSARAGAGSGSSPGGQSPASGNVTGNSNSTFISSGQVM
NFKGDIIVVYVSQTSQEGAAAAAEPMGRPVQEETLARRDSFAGNGPRFPDPCGGPEGLRE
PEKASRPVQEQGGAKA
Function Involved in the regulation of interactions between T-cells and dendritic cells. Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
NF-kappa B signaling pathway (hsa04064 )
Osteoclast differentiation (hsa04380 )
Prolactin signaling pathway (hsa04917 )
Rheumatoid arthritis (hsa05323 )
Reactome Pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (R-HSA-5676594 )
TNFR2 non-canonical NF-kB pathway (R-HSA-5668541 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
6 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 109490 DMDVE6A Discovery agent N.A. Investigative [1]
ISIS 109491 DMISNWV Discovery agent N.A. Investigative [1]
ISIS 109502 DMRPMN6 Discovery agent N.A. Investigative [1]
ISIS 109524 DMJ7EDV Discovery agent N.A. Investigative [1]
ISIS 109525 DMB28D3 Discovery agent N.A. Investigative [1]
ISIS 109526 DMZN60F Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 6 Investigative Drug(s)

References

1 US patent application no. 6,171,860, Antisense inhibition of rank expression.