Details of the Drug Therapeutic Target (DTT) | DrugMAP

General Information of Drug Therapeutic Target (DTT) (ID: TT3LE7P)

DTT Name	Gastric alcohol dehydrogenase (ADH7)
Synonyms	Alcohol dehydrogenase class IV mu/sigma chain; Alcohol dehydrogenase class 4 mu/sigma chain; ADH7
Gene Name	ADH7
DTT Type	Literature-reported target				[1]
BioChemical Class	Short-chain dehydrogenases reductase
UniProt ID	ADH7_HUMAN
TTD ID	T09770
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 1.1.1.1
Sequence	MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICR TDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPD GNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEK VCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDK FEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGT SVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITH VLPFKKISEGFELLNSGQSIRTVLTF
Function	Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.
KEGG Pathway	Glycolysis / Gluconeogenesis (hsa00010 ) Fatty acid degradation (hsa00071 ) Tyrosine metabolism (hsa00350 ) Pyruvate metabolism (hsa00620 ) Retinol metabolism (hsa00830 ) Metabolism of xenobiotics by cytochrome P450 (hsa00980 ) Drug metabolism - cytochrome P450 (hsa00982 ) Metabolic pathways (hsa01100 ) Alcoholic liver disease (hsa04936 )
Reactome Pathway	Ethanol oxidation (R-HSA-71384 )

The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Gastric alcohol dehydrogenase (ADH7) DME Info

Gene Name

ADH7

2 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[2]
NADH	DM5NM6E	Parkinson disease	8A00.0	Approved	[3]
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References

1	Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice. Toxicol Lett. 2017 Jan 4;265:17-22.
2	Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42.
3	Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12.