Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT3LJ9K)

DTT Name VEGF messenger RNA (VEGF mRNA)
Synonyms Vascular permeability factor (mRNA); Vascular endothelial growth factor A (mRNA); VPF (mRNA); VEGF-A (mRNA); VEGF (mRNA)
Gene Name VEGFA
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
VEGFA_HUMAN
TTD ID
T58479
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Function
Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.
KEGG Pathway
Ras signaling pathway (hsa04014 )
Rap1 signaling pathway (hsa04015 )
Cytokine-cytokine receptor interaction (hsa04060 )
HIF-1 signaling pathway (hsa04066 )
mTOR signaling pathway (hsa04150 )
PI3K-Akt signaling pathway (hsa04151 )
VEGF signaling pathway (hsa04370 )
Focal adhesion (hsa04510 )
Pathways in cancer (hsa05200 )
Proteoglycans in cancer (hsa05205 )
MicroRNAs in cancer (hsa05206 )
Renal cell carcinoma (hsa05211 )
Pancreatic cancer (hsa05212 )
Bladder cancer (hsa05219 )
Rheumatoid arthritis (hsa05323 )
Reactome Pathway
Regulation of gene expression by Hypoxia-inducible Factor (R-HSA-1234158 )
VEGF ligand-receptor interactions (R-HSA-194313 )
VEGF binds to VEGFR leading to receptor dimerization (R-HSA-195399 )
Platelet degranulation (R-HSA-114608 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALN-VEG01 DMT584A Macular degeneration 9B78.3 Terminated [1]
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References

1 Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals.