Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT3PKZE)

DTT Name	Corticotropin-releasing factor binding protein (CRHBP)
Synonyms	Corticotropin-releasing hormone-binding protein; Corticotropin-releasing factor-binding protein; CRH-BP; CRFBP; CRF-binding protein; CRF-BP
Gene Name	CRHBP
DTT Type	Literature-reported target	[1]
UniProt ID	CRHBP_HUMAN
TTD ID	T36423
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRC LDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKG EKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNL FPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGI GDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQ LEPYELENPNGNSIGEFCLSGL
Function	May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Binds CRF and inactivates it.
Reactome Pathway	Class B/2 (Secretin family receptors) (R-HSA-373080 )

References

1	Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicot... Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15475-80.