Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT3RMNA)

DTT Name Chymotrypsin-C (CLCR)
Synonyms Caldecrin; CLCR
Gene Name CTRC
DTT Type
Patented-recorded target
 [1]
UniProt ID
CTRC_HUMAN
TTD ID
T10118
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 3.4.21.2
Sequence
MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCG
GTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRN
DIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPV
VDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSR
RGCNTRKKPVVYTRVSAYIDWINEKMQL
Function
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
4 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
AC1LCOK0 DMFWYKE N. A. N. A. Patented [2]
STK296197 DM6KPYL N. A. N. A. Patented [2]
Z223457004 DMUOZEJ N. A. N. A. Patented [2]
Z90308237 DMRBFUA N. A. N. A. Patented [2]
------------------------------------------------------------------------------------
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID12372533C20 DMIW5TY Discovery agent N.A. Investigative [1]
------------------------------------------------------------------------------------

References

1 P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3199-202.
2 Benzoxazinone derivatives for treatment of skin diseases. US9695194.