Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT45KOB)

DTT Name	GATA-binding factor 3 (GATA3)
Synonyms	Trans-acting T-cell-specific transcription factor GATA-3
Gene Name	GATA3
DTT Type	Literature-reported target	[1]
BioChemical Class	Zinc-finger
UniProt ID	GATA3_HUMAN
TTD ID	T92635
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHV PPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKT SIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDE KECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLL GGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPL IKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEG IQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPT PMHPPSSLSFGPHHPSSMVTAMG
Function	Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.
KEGG Pathway	Th1 and Th2 cell differentiation (hsa04658 ) Th17 cell differentiation (hsa04659 ) Parathyroid hormone synthesis, secretion and action (hsa04928 ) Inflammatory bowel disease (hsa05321 )
Reactome Pathway	Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807 ) RUNX1 regulates transcription of genes involved in differentiation of HSCs (R-HSA-8939236 ) Estrogen-dependent gene expression (R-HSA-9018519 ) Factors involved in megakaryocyte development and platelet production (R-HSA-983231 ) Ub-specific processing proteases (R-HSA-5689880 )

References

1	Upregulation of the transcription factor GATA-3 in upper airway mucosa after in vivo and in vitro allergen challenge. J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1146-52.