Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4FJ3A)

DTT Name	PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1)
Synonyms	TRF1-interacting protein 1; Protein 67-11-3; Pin2-interacting protein X1; Liver-related putative tumor suppressor; LPTS; LPTL
Gene Name	PINX1
DTT Type	Literature-reported target	[1]
UniProt ID	PINX1_HUMAN
TTD ID	T59136
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQV KNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKIS KNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQE YFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKP ERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKK KLQKPVEIAEDATLEETLVKKKKKKDSK
Function	Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Microtubule-binding protein essential for faithful chromosome segregation.

References

1	Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity. Sci Rep. 2017 Mar 3;7:43650.