Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4LRVO)

DTT Name Gastrin (GAST)
Synonyms Gastrin6; GAST; G52; G34; G14
Gene Name GAST
DTT Type
Clinical trial target
 [1]
BioChemical Class
Gastrin cholecystokinin
UniProt ID
GAST_HUMAN
TTD ID
T16128
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRLCVYVLIFALALAAFSEASWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQL
GPQGPPHLVADPSKKQGPWLEEEEEAYGWMDFGRRSAEDEN
Function
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
KEGG Pathway
Gastric acid secretion (hsa04971 )
Reactome Pathway
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907 )
G alpha (q) signalling events (R-HSA-416476 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
G17DT DMMNP2F Gastric adenocarcinoma 2B72 Phase 3 [1]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Gastric cancer 2C82 Gastric tissue 7.86E-01 -0.93 -0.75
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References

1 G17DT: an antigastrin immunogen for the treatment of gastrointestinal malignancy. Expert Opin Biol Ther. 2007 Mar;7(3):397-404.