Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TT4NXYM)
DTT Name | Human immunodeficiency virus Negative factor (HIV nef) | ||||
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Synonyms | nef; Nef protein; F-protein; 3'ORF; 27 kDa protein | ||||
Gene Name | HIV nef | ||||
DTT Type |
Clinical trial target
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[1] | |||
BioChemical Class |
Lentivirus primate group Nef
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UniProt ID | |||||
TTD ID | |||||
Sequence |
MGGKWSKRSMGGWSAIRERMRRAEPRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCA
WLEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYH TQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKVEEANEGENNSLLHPMSLHGMEDA EKEVLVWRFDSKLAFHHMARELHPEYYKDC |
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Function | Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors. | ||||
Molecular Interaction Atlas (MIA) of This DTT
Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||||||||||||||||||||
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4 Clinical Trial Drug(s) Targeting This DTT
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1 Discontinued Drug(s) Targeting This DTT
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1 Investigative Drug(s) Targeting This DTT
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References