Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4P8O2)

• DTT Name: HUMAN FK506 binding protein 10 (FKBP10)
• Synonyms: Rotamase; PPIase FKBP10; Peptidyl-prolyl cis-trans isomerase FKBP10; Immunophilin FKBP65; FKBP-65; FKBP-10; FK506-binding protein 10; 65 kDa FKBP; 65 kDa FK506-binding protein
• Gene Name: FKBP10
• UniProt ID: FKB10_HUMAN
• TTD ID: T01603
• EC Number: EC 5.2.1.8
• Sequence:
  MFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQ
  MGDFVRYHYNGTFEDGKKFDSSYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVP
  PHLGYGSIGLAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYH
  YNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEK
  GYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDG
  TLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPG
  SAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFTSH
  DYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEV
  ELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPG
  QDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEEL
• Function: Human protein FK506 binding protein 10 interacts with SARS-CoV-2 Orf8 protein with high significance, which indicates FKBP10 as a potential therapeutic target.

References

• [1] A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.