Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4PTJ7)

• DTT Name: Ribonuclease P protein (RPP)
• Synonyms: Ribonuclease P protein
• Gene Name: RPP14
• DTT Type: Discontinued target; [1]
• BioChemical Class: Endoribonucleases
• UniProt ID: RPP14_HUMAN ; RPP21_HUMAN
• TTD ID: T28532
• Sequence:
  MPAPAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQLLISAVKDLFGEVDAALP
  LDILTYEEKTLSAILRICSSGLVKLWSSLTLLGSYKGKKCAFRVIQVSPFLLALSGNSRE
  LVLD
• Function: Acts as a catalyst in the same way that a protein-based enzyme would. Its function is to cleave off an extra, or precursor, sequence of RNA on tRNA molecules.
• Reactome Pathway:
  Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)
  tRNA processing in the nucleus (R-HSA-6784531)

Molecular Interaction Atlas (MIA) of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etarotene	DM3OUT0	Psoriasis vulgaris	EA90	Discontinued in Phase 3	[1]

References

• [1] Retinoids inhibit human epidermal keratinocyte RNase P activity. Biol Chem. 2003 Mar;384(3):457-62.