Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4UJX5)

DTT Name	Carboxypeptidase B1 (CPB1)
Synonyms	Pancreas-specific protein; PASP; Carboxypeptidase B; CPB
Gene Name	CPB1
DTT Type	Patented-recorded target	[1]
BioChemical Class	Peptidase
UniProt ID	CBPB1_HUMAN
TTD ID	T36725
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.4.17.2
Sequence	MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQ IKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYN KWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREW ISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTH TGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAY LTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAG GSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY
Function	A carboxypeptidase that preferentially acts upon basic amino acids, such as arginine and lysine. Responsible for rapidly metabolizing the C5a protein into C5a des-Arg, with one less amino acid.
KEGG Pathway	Pancreatic secretion (hsa04972 ) Protein digestion and absorption (hsa04974 )
Reactome Pathway	Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

3 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8710232, 1	DMCNAM9	N. A.	N. A.	Patented	[2]
US8710232, 7	DMCNS9T	N. A.	N. A.	Patented	[2]
US8710232, 8	DM1MQ7J	N. A.	N. A.	Patented	[2]
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2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID14640538C3	DMR2L6X	Discovery agent	N.A.	Investigative	[1]
PMID19954973C4	DMDYZE5	Discovery agent	N.A.	Investigative	[3]
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References

1	Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem. 2003 Dec 4;46(25):5294-7.
2	Imidazole derivatives used as TAFIa inhibitors. US8710232.
3	Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett. 2010 Jan 1;20(1):92-6.