Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4VHL6)

DTT Name Inward rectifier potassium channel Kir3.3 (KCNJ9)
Synonyms Potassium channel, inwardly rectifying subfamily J member 9; Inward rectifier K(+) channel Kir3.3; GIRK3; GIRK-3; G protein-activated inward rectifier potassium channel 3
Gene Name KCNJ9
DTT Type
Literature-reported target
 [1]
BioChemical Class
Inward rectifier potassium channel
UniProt ID
KCNJ9_HUMAN
TTD ID
T53186
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLS
LLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETT
IGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVS
LRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLF
LVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLW
GHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEK
VEEEGAGEGAGGEAGADKEQNGCLPPPESESKV
Function
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).
KEGG Pathway
Circadian entrainment (hsa04713 )
Retrograde endocannabinoid signaling (hsa04723 )
Serotonergic synapse (hsa04726 )
Dopaminergic synapse (hsa04728 )
Estrogen signaling pathway (hsa04915 )
Oxytocin signaling pathway (hsa04921 )
GnRH secretion (hsa04929 )
Morphine addiction (hsa05032 )
Reactome Pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (R-HSA-997272 )
Activation of G protein gated Potassium channels (R-HSA-1296041 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
PIP2 DMOZV7N Discovery agent N.A. Investigative [1]
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References

1 Regulation of cardiac Na+,Ca2+ exchange and KATP potassium channels by PIP2. Science. 1996 Aug 16;273(5277):956-9.