Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4VQZX)

• DTT Name: Cholestenol delta-isomerase (EBP)
• Synonyms: Emopamilbinding protein; EBP; Delta(8)Delta(7) sterol isomerase; D8D7 sterol isomerase; 3betahydroxysteroidDelta(8),Delta(7)isomerase
• Gene Name: EBP
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Intramolecular oxidoreductases
• UniProt ID: EBP_HUMAN
• TTD ID: T25317
• EC Number: EC 5.3.3.5
• Sequence:
  MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
  WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
  METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
  HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
• Function: Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
• KEGG Pathway:
  Steroid biosynthesis (hsa00100)
  Metabolic pathways (hsa01100)
• Reactome Pathway:
  Cholesterol biosynthesis via lathosterol (R-HSA-6807062)
  Cholesterol biosynthesis via desmosterol (R-HSA-6807047)
• BioCyc Pathway: MetaCyc:ENSG00000147155-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SR-31747	DMQSN7B	Rheumatoid arthritis	FA20	Phase 2	[1]

Molecular Expression Atlas (MEA) of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Rheumatoid arthritis	FA20	Synovial tissue	3.15E-03	0.25	0.89

References

• [1] Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther. 1998 Jun;285(3):1296-302.