Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT53XHB)

DTT Name CD86 messenger RNA (CD86 mRNA)
Synonyms T-lymphocyte activation antigen CD86 (mRNA); FUN-1 (mRNA); CTLA-4 counter-receptor B7.2 (mRNA); CD86 (mRNA); CD28LG2 (mRNA); BU63 (mRNA); B70 (mRNA); Activation B7-2 antigen (mRNA)
Gene Name CD86
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
CD86_HUMAN
TTD ID
T97783
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQ
ENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGM
IRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTI
EYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQ
PPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREK
IHIPERSDEAQRVFKSSKTSSCDKSDTCF
Function
May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4.
KEGG Pathway
Cell adhesion molecules (CAMs) (hsa04514 )
Toll-like receptor signaling pathway (hsa04620 )
Intestinal immune network for IgA production (hsa04672 )
Type I diabetes mellitus (hsa04940 )
Transcriptional misregulation in cancer (hsa05202 )
Autoimmune thyroid disease (hsa05320 )
Systemic lupus erythematosus (hsa05322 )
Rheumatoid arthritis (hsa05323 )
Allograft rejection (hsa05330 )
Graft-versus-host disease (hsa05332 )
Viral myocarditis (hsa05416 )
Reactome Pathway
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530 )
CD28 co-stimulation (R-HSA-389356 )
CD28 dependent PI3K/Akt signaling (R-HSA-389357 )
CD28 dependent Vav1 pathway (R-HSA-389359 )
CTLA4 inhibitory signaling (R-HSA-389513 )
PIP3 activates AKT signaling (R-HSA-1257604 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
4 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 10373 DM60CBI Discovery agent N.A. Investigative [1]
ISIS 113131 DM063XM Discovery agent N.A. Investigative [2]
ISIS 9133 DMDKB1I Discovery agent N.A. Investigative [1]
ISIS 9139 DMGOPHN Discovery agent N.A. Investigative [1]
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References

1 US patent application no. 6,319,906, Oligonucleotide compositions and methods for the modulation of the expression of B7 protein.
2 US patent application no. 7,425,545, Modulation of C-reactive protein expression.