Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT56RYE)

DTT Name	Mesencephalic astrocyte-derived neurotrophic factor (ARMET)
Synonyms	Mesencephalic astrocytederived neurotrophic factor; MANF; Argininerich protein
Gene Name	MANF
DTT Type	Literature-reported target	[1]
UniProt ID	MANF_HUMAN
TTD ID	T62415
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MRRMWATQGLAVALALSVLPGSRALRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENEL IKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELK YDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASART DL
Function	Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
Reactome Pathway	Platelet degranulation (R-HSA-114608 )

References

1	Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for ... Hum Mol Genet. 2013 Dec 20;22(25):5262-75.