Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5AHZ0)

DTT Name	Alcohol dehydrogenase 1A (ADH1A)
Synonyms	Alcohol dehydrogenase subunit alpha; ADH1
Gene Name	ADH1A
DTT Type	Successful target	[1]
UniProt ID	ADH1A_HUMAN
TTD ID	T65570
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 1.1.1.1
Sequence	MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVT PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNP QGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTG YGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATE CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQ NLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGF DLLHSGKSIRTILMF
Function	Facilitates the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD+) to NADH.
KEGG Pathway	Glycolysis / Gluconeogenesis (hsa00010 ) Fatty acid degradation (hsa00071 ) Tyrosine metabolism (hsa00350 ) Pyruvate metabolism (hsa00620 ) Retinol metabolism (hsa00830 ) Metabolism of xenobiotics by cytochrome P450 (hsa00980 ) Drug metabolism - cytochrome P450 (hsa00982 ) Metabolic pathways (hsa01100 ) Alcoholic liver disease (hsa04936 )
Reactome Pathway	RA biosynthesis pathway (R-HSA-5365859 ) Ethanol oxidation (R-HSA-71384 ) Abacavir metabolism (R-HSA-2161541 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Alcohol dehydrogenase class-I alpha (ADH1A) DME Info

Gene Name

ADH1A

3 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[2]
NADH	DM5NM6E	Parkinson disease	8A00.0	Approved	[3]
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[4]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
2	Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
3	Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12.
4	Pharmacokinetics and disposition of silodosin (KMD-3213). Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45.