General Information of Drug Therapeutic Target (DTT) (ID: TT5HNVS)

DTT Name Melanoma derived growth regulator (MIA)
Synonyms Melanoma-derived growth regulatory protein; Melanoma inhibitory activity protein
Gene Name MIA
DTT Type
Literature-reported target
[1]
UniProt ID
MIA_HUMAN
TTD ID
T78350
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARSLVCLGVIILLSAFSGPGVRGGPMPKLADRKLCADQECSHPISMAVALQDYMAPDCR
FLTIHRGQVVYVFSKLKGRGRLFWGGSVQGDYYGDLAARLGYFPSSIVREDQTLKPGKVD
VKTDKWDFYCQ
Function Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

References

1 Melanoma-derived factors alter the maturation and activation of differentiated tissue-resident dendritic cells. Immunol Cell Biol. 2016 Jan;94(1):24-38.