Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5S8DR)

DTT Name APOA1 messenger RNA (APOA1 mRNA)
Synonyms Truncated apolipoprotein AI (mRNA); Apolipoprotein A1 (mRNA); Apolipoprotein A-I (mRNA); ApoAI (mRNA); ApoA-I (mRNA); Apo-AI (mRNA)
Gene Name APOA1
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
APOA1_HUMAN
TTD ID
T90163
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
GLLPVLESFKVSFLSALEEYTKKLNTQ
Function
As part of the SPAP complex, activates spermatozoa motility. Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
KEGG Pathway
PPAR signaling pathway (hsa03320 )
Fat digestion and absorption (hsa04975 )
Vitamin digestion and absorption (hsa04977 )
African trypanosomiasis (hsa05143 )
Reactome Pathway
ABC transporters in lipid homeostasis (R-HSA-1369062 )
Chylomicron-mediated lipid transport (R-HSA-174800 )
HDL-mediated lipid transport (R-HSA-194223 )
PPARA activates gene expression (R-HSA-1989781 )
Scavenging of heme from plasma (R-HSA-2168880 )
Scavenging by Class B Receptors (R-HSA-3000471 )
Scavenging by Class A Receptors (R-HSA-3000480 )
Retinoid metabolism and transport (R-HSA-975634 )
Amyloid formation (R-HSA-977225 )
Platelet degranulation (R-HSA-114608 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 144368 DMJW4C5 Discovery agent N.A. Investigative [1]
ISIS 144379 DM1QLB0 Discovery agent N.A. Investigative [1]
ISIS 144396 DMY34RB Discovery agent N.A. Investigative [1]
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References

1 US patent application no. 7,259,150, Modulation of apolipoprotein (a) expression.