Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5SOEU)

• DTT Name: Hsp90 co-chaperone Cdc37 (CDC37)
• Synonyms: p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
• Gene Name: CDC37
• DTT Type: Literature-reported target; [1]
• UniProt ID: CDC37_HUMAN
• TTD ID: T94366
• Sequence:
  MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRK
  VAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLS
  KDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVH
  LVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTK
  IKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYES
  LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPG
  DPLLEAVPKTGDEKDVSV
• Function: Inhibits HSP90AA1 ATPase activity. Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
• KEGG Pathway: PI3K-Akt signaling pathway (hsa04151)
• Reactome Pathway:
  Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382)
  Constitutive Signaling by EGFRvIII (R-HSA-5637810)
  Regulation of necroptotic cell death (R-HSA-5675482)
  Downregulation of ERBB2 signaling (R-HSA-8863795)
  RHOBTB2 GTPase cycle (R-HSA-9013418)
  Constitutive Signaling by Overexpressed ERBB2 (R-HSA-9634285)
  Drug-mediated inhibition of ERBB2 signaling (R-HSA-9652282)
  Signaling by ERBB2 KD Mutants (R-HSA-9664565)
  Resistance of ERBB2 KD mutants to trastuzumab (R-HSA-9665233)
  Resistance of ERBB2 KD mutants to sapitinib (R-HSA-9665244)
  Resistance of ERBB2 KD mutants to tesevatinib (R-HSA-9665245)
  Resistance of ERBB2 KD mutants to neratinib (R-HSA-9665246)
  Resistance of ERBB2 KD mutants to osimertinib (R-HSA-9665247)
  Resistance of ERBB2 KD mutants to afatinib (R-HSA-9665249)
  Resistance of ERBB2 KD mutants to AEE788 (R-HSA-9665250)
  Resistance of ERBB2 KD mutants to lapatinib (R-HSA-9665251)
  Signaling by ERBB2 ECD mutants (R-HSA-9665348)
  Signaling by ERBB2 TMD/JMD mutants (R-HSA-9665686)
  Drug resistance in ERBB2 TMD/JMD mutants (R-HSA-9665737)
  Signaling by ERBB2 (R-HSA-1227986)

References

• [1] The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. J Biol Chem. 2011 May 13;286(19):16976-83.