Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5T3P6)

DTT Name	Tissue kallikrein (KLK1)
Synonyms	Kidney/pancreas/salivary gland kallikrein; Kallikrein1; Kallikrein-1
Gene Name	KLK1
DTT Type	Literature-reported target	[1]
BioChemical Class	Peptidase
UniProt ID	KLK1_HUMAN
TTD ID	T40000
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.4.21.35
Sequence	MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK PSVAVRVLSYVKWIEDTIAENS
Function	Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
KEGG Pathway	Endocrine and other factor-regulated calcium reabsorption (hsa04961 )
Reactome Pathway	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
example 131 [WO2009133348]	DMSG8RI	Discovery agent	N.A.	Investigative	[1]
SBTI	DMDBLGQ	Discovery agent	N.A.	Investigative	[2]
VA-118020	DM65GQD	Respiratory disease	CB40	Investigative	[1]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2865).
2	Expression and characterization of human tissue kallikrein variants. Protein Expr Purif. 1998 Apr;12(3):361-70.