General Information of Drug Therapeutic Target (DTT) (ID: TT5T8MR)

DTT Name NADPH oxidase 2 (CYBB)
Synonyms
p22 phagocyte Bcytochrome; p22 phagocyte B-cytochrome; gp91phox; gp911; gp91-phox; gp91-1; Superoxidegenerating NADPH oxidase heavy chain subunit; Superoxide-generating NADPH oxidase heavy chain subunit; Neutrophil cytochrome b 91 kDa polypeptide; NOX2; Hemebinding membrane glycoprotein gp91phox; Heme-binding membrane glycoprotein gp91phox; Cytochrome b558 subunit beta; Cytochrome b245 heavy chain; Cytochrome b-245 heavy chain; Cytochrome b(558) subunit beta; CGD91phox; CGD91-phox
Gene Name CYBB
DTT Type
Literature-reported target
[1]
BioChemical Class
Phagocyte NADPH oxidase
UniProt ID
CY24B_HUMAN
TTD ID
T36729
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.-.-.-
Sequence
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACL
NFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHL
FNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGV
VITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHN
ITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKV
VTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGD
WTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASIL
KSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYL
TGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPE
ALAETLSKQSISNSESGPRGVHFIFNKENF
Function
It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Critical component of the membrane-bound oxidase of phagocytes that generates superoxide.
KEGG Pathway
HIF-1 signaling pathway (hsa04066 )
Phagosome (hsa04145 )
Ferroptosis (hsa04216 )
Necroptosis (hsa04217 )
Neutrophil extracellular trap formation (hsa04613 )
NOD-like receptor signaling pathway (hsa04621 )
Leukocyte transendothelial migration (hsa04670 )
AGE-RAGE signaling pathway in diabetic complications (hsa04933 )
Alzheimer disease (hsa05010 )
Prion disease (hsa05020 )
Pathways of neurodegeneration - multiple diseases (hsa05022 )
Leishmaniasis (hsa05140 )
Coronavirus disease - COVID-19 (hsa05171 )
Diabetic cardiomyopathy (hsa05415 )
Lipid and atherosclerosis (hsa05417 )
Reactome Pathway
Cross-presentation of particulate exogenous antigens (phagosomes) (R-HSA-1236973 )
Detoxification of Reactive Oxygen Species (R-HSA-3299685 )
VEGFA-VEGFR2 Pathway (R-HSA-4420097 )
RHO GTPases Activate NADPH Oxidases (R-HSA-5668599 )
Neutrophil degranulation (R-HSA-6798695 )
RAC1 GTPase cycle (R-HSA-9013149 )
RAC2 GTPase cycle (R-HSA-9013404 )
RAC3 GTPase cycle (R-HSA-9013423 )
ROS and RNS production in phagocytes (R-HSA-1222556 )

References

1 NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury. Oxid Med Cell Longev. 2017;2017:6057609.