Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5VER7)

DTT Name Bacterial Undecaprenyl pyrophosphate synthetase (Bact ispU)
Synonyms ispU; Undecaprenyl diphosphate synthase; Undecaprenyl diphosphate synthase; UPP synthetase; UPP synthase; UDS; Di-trans-poly-cis-decaprenylcistransferase
Gene Name Bact ispU
DTT Type
Literature-reported target
 [1]
BioChemical Class
Alkyl aryl transferase
UniProt ID
UPPS_ECOLI
TTD ID
T34337
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.5.1.31
Sequence
MMLSATQPLSEKLPAHGCRHVAIIMDGNGRWAKKQGKIRAFGHKAGAKSVRRAVSFAANN
GIEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTSRFNSRL
QERIRKSEALTAGNTGLTLNIAANYGGRWDIVQGVRQLAEKVQQGNLQPDQIDEEMLNQH
VCMHELAPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDEQDFEGALNAFANRE
RRFGGTEPGDETA
Function
Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
KEGG Pathway
Peptidoglycan biosynthesis (ecj00550 )
Terpenoid backbone biosynthesis (ecj00900 )
Biosynthesis of secondary metabolites (ecj01110 )
BioCyc Pathway
MetaCyc:UPPSYN-MON
EcoCyc:UPPSYN-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-pentenylbutanedioic acid 32 DMT7RXZ Discovery agent N.A. Investigative [2]
ISOPENTENYL PYROPHOSPHATE DMTU05Y Discovery agent N.A. Investigative [1]
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References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2 Synthesis and biological activity of isopentenyl diphosphate analogues. Bioorg Med Chem. 2004 Feb 15;12(4):763-70.