Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5YPJF)

• DTT Name: CD80-PD-L1 interaction (CD80/PD-L1 PPI)
• Synonyms: T-lymphocyte activation antigen CD80/Programmed cell death 1 ligand 1 PPI
• Gene Name: CD80-CD274
• DTT Type: Patented-recorded target; [1]
• UniProt ID: CD80_HUMAN-PD1L1_HUMAN
• TTD ID: T18551
• Sequence:
  MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
  DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
  ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
  TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
  LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEETMGHTRRQGTS
  PSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEK
  KMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREH
  LAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVS
  QDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAIT
  LISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
• Function: Augments activated alloreactive CD4+ T cell proliferation and apoptosis and ameliorates acute graft versus host disease

Molecular Interaction Atlas (MIA) of This DTT

13 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Biaryl compound 1	DMHEAJQ	Hepatitis	DB97.Z	Patented	[1]
Biaryl compound 2	DMS8VYE	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 1	DMN7I9C	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 2	DM5OEQZ	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 3	DMYGFTI	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 4	DMOQBN4	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 5	DMK3UJY	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 6	DMQ84KW	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 7	DMP2JF0	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 8	DMOMTBE	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 9	DMARU0E	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example11	DMD65GU	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example12	DMN2K10	Hepatitis	DB97.Z	Patented	[1]

References

• [1] A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678.