Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT613U4)

• DTT Name: Tripartite motif-containing 59 (TRIM59)
• Synonyms: Tumor suppressor TSBF-1; TSBF1; TRIM57; RNF104; RING finger protein 104
• Gene Name: TRIM59
• DTT Type: Literature-reported target; [1]
• BioChemical Class: TRIM/RBCC family
• UniProt ID: TRI59_HUMAN
• TTD ID: T92902
• Sequence:
  MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNFYIWRPLRIPLKCPNCR
  SITEIAPTGIESLPVNFALRAIIEKYQQEDHPDIVTCPEHYRQPLNVYCLLDKKLVCGHC
  LTIGQHHGHPIDDLQSAYLKEKDTPQKLLEQLTDTHWTDLTHLIEKLKEQKSHSEKMIQG
  DKEAVLQYFKELNDTLEQKKKSFLTALCDVGNLINQEYTPQIERMKEIREQQLELMALTI
  SLQEESPLKFLEKVDDVRQHVQILKQRPLPEVQPVEIYPRVSKILKEEWSRTEIGQIKNV
  LIPKMKISPKRMSCSWPGKDEKEVEFLKILNIVVVTLISVILMSILFFNQHIITFLSEIT
  LIWFSEASLSVYQSLSNSLHKVKNILCHIFYLLKEFVWKIVSH
• Function: May serve as a multifunctional regulator for innate immune signaling pathways.

References

• [1] Tripartite Motif-Containing Protein 59 (TRIM59) Promotes Epithelial Ovarian Cancer Progression via the Focal Adhesion Kinase(FAK)/AKT/Matrix Metall... Med Sci Monit. 2019 May 7;25:3366-3373.