Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT62BC7)

• DTT Name: Gamma-glutamyl transferase 7 (GGT7)
• Synonyms: Glutathione hydrolase 7; Gamma-glutamyltranspeptidase 7; Gamma-glutamyltransferase-like 5; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase 7 light chain; Gamma-glutamyltransferase 7; GGTL5; GGTL3; GGT7; GGT 7
• Gene Name: GGT7
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Peptidase
• UniProt ID: GGT7_HUMAN
• TTD ID: T25122
• EC Number: EC 3.4.19.13
• Sequence:
  MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDS
  FLKSARLQRLPSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFATG
  VTVALVMQIYFGDPQIFQQGAVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGIVAPH
  SSGLGGGGVMLVHDIRRNESHLIDFRESAPGALREETLQRSWETKPGLLVGVPGMVKGLH
  EAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARALAEQLPPNMSERFRETFLPSGRPPL
  PGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVITEEDFSNYSALVEK
  PVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAETLKIALALAS
  RLGDPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDGAPTAAQVLIMG
  PDDFIVAMVSSLNQPFGSGLITPSGILLNSQMLDFSWPNRTANHSAPSLENSVQPGKRPL
  SFLLPTVVRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDL
  QSNLLQVDSEFTEEEIEFLEARGHHVEKVDVLSWVHGSRRTNNFIIAVKDPRSPDAAGAT
  IL
• Function: Involved in the pathway glutathione metabolism, which is part of Sulfur metabolism. Cleaves glutathione conjugates. Glutathione hydrolase activity. Hypoglycin A gamma-glutamyl transpeptidase activity. Leukotriene C4 gamma-glutamyl transferase activity. Peptidyltransferase activity.
• KEGG Pathway:
  Taurine and hypotaurine metabolism (hsa00430)
  Glutathione metabolism (hsa00480)
  Metabolic pathways (hsa01100)
• Reactome Pathway:
  Aflatoxin activation and detoxification (R-HSA-5423646)
  Paracetamol ADME (R-HSA-9753281)
  Glutathione synthesis and recycling (R-HSA-174403)

References

• [1] -Glutamyl transferase 7 is a novel regulator of glioblastoma growth. BMC Cancer. 2015 Apr 7;15:225.