Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT64ZVP)

• DTT Name: Relaxin-3 receptor 1 (RXFP3)
• Synonyms: Somatostatin- and angiotensin-like peptide receptor; SALPR; Relaxin family peptide receptor 3; RLN3R1; RLN3 receptor 1; G-protein coupled receptor GPCR135; G protein-coupled receptor SALPR
• Gene Name: RXFP3
• DTT Type: Literature-reported target; [1]
• UniProt ID: RL3R1_HUMAN
• TTD ID: T88944
• Sequence:
  MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGA
  PPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLF
  VTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTR
  YHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVK
  VMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAA
  GTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFS
  QEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTA
  TTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
• Function: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
• KEGG Pathway:
  Neuroactive ligand-receptor interaction (hsa04080)
  Relaxin signaling pathway (hsa04926)
• Reactome Pathway:
  Relaxin receptors (R-HSA-444821)
  G alpha (i) signalling events (R-HSA-418594)

Molecular Interaction Atlas (MIA) of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
135PAM1	DMMTPK3	Discovery agent	N.A.	Investigative	[1]

References

• [1] In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. PLoS One. 2012;7(2):e30792.