Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT67TDP)

DTT Name	Lanosterol 14-alpha demethylase (CYP51A1)
Synonyms	Cytochrome P450LI; Cytochrome P45014DM; Cytochrome P450-14DM; Cytochrome P450 51A1
Gene Name	CYP51A1
DTT Type	Clinical trial target	[1]
BioChemical Class	Cytochrome P450 family
UniProt ID	CP51A_HUMAN
TTD ID	T32972
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 1.14.14.154
Sequence	MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKS PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS KNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDL NLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFP TVNYTTMIHTPENPVIRYKRRSK
Function	Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
KEGG Pathway	Steroid biosynthesis (hsa00100 ) Metabolic pathways (hsa01100 )
Reactome Pathway	Endogenous sterols (R-HSA-211976 ) Activation of gene expression by SREBF (SREBP) (R-HSA-2426168 ) EGR2 and SOX10-mediated initiation of Schwann cell myelination (R-HSA-9619665 ) Cholesterol biosynthesis (R-HSA-191273 )
BioCyc Pathway	MetaCyc:HS00076-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VT-1129	DMCGK9H	Onchocerciasis	1F6A	Phase 2	[1]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)