Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6LPFO)

DTT Name	Transforming protein RhoB (RHOB)
Synonyms	RhoB
Gene Name	RHOB
DTT Type	Literature-reported target	[1]
UniProt ID	RHOB_HUMAN
TTD ID	T58361
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDT AGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKD LRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQ KRYGSQNGCINCCKVL
Function	Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
KEGG Pathway	Salmonella infection (hsa05132 )
Reactome Pathway	G alpha (12/13) signalling events (R-HSA-416482 ) Sema4D induced cell migration and growth-cone collapse (R-HSA-416572 ) RHO GTPases activate PKNs (R-HSA-5625740 ) RHO GTPases activate CIT (R-HSA-5625900 ) RHO GTPases Activate ROCKs (R-HSA-5627117 ) RHO GTPases Activate Formins (R-HSA-5663220 ) RHO GTPases Activate Rhotekin and Rhophilins (R-HSA-5666185 ) RHOB GTPase cycle (R-HSA-9013026 ) GPVI-mediated activation cascade (R-HSA-114604 )

References

1	RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev. 2003 Nov 1;17(21):2721-32.