Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6U071)

• DTT Name: Prohibitin (PHB)
• Synonyms: PHB1; HEL-S-54e; HEL-215
• Gene Name: PHB
• DTT Type: Literature-reported target; [1]
• UniProt ID: PHB_HUMAN
• TTD ID: T96396
• Sequence:
  MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPW
  VQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLP
  SITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFT
  EAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRK
  LEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
• Function: It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. Prohibitin inhibits DNA synthesis.
• Reactome Pathway:
  Signaling by moderate kinase activity BRAF mutants (R-HSA-6802946)
  Paradoxical activation of RAF signaling by kinase inactive BRAF (R-HSA-6802955)
  Processing of SMDT1 (R-HSA-8949664)
  Signaling downstream of RAS mutants (R-HSA-9649948)
  RAF activation (R-HSA-5673000)

References

• [1] Prohibitin: a potential target for new therapeutics. Trends Mol Med. 2005 Apr;11(4):192-7.