Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6YF5K)

• DTT Name: Cytokine receptor-like factor 1 (CRLF1)
• Synonyms: ZcytoR5; Cytokine-like factor 1; CLF-1
• Gene Name: CRLF1
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Type I cytokine receptor family. Type 3 subfamily
• UniProt ID: CRLF1_HUMAN
• TTD ID: T94313
• Sequence:
  MPAGRRGPAAQSARRPPPLLPLLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATC
  SVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARD
  GSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQ
  DNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPD
  VHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAG
  LKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPGPGGGACEPRGGEPSS
  GPVRRELKQFLGWLKKHAYCSNLSFRLYDQWRAWMQKSHKTRNQDEGILPSGRRGTARGP
  AR
• Function: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.
• Reactome Pathway:
  Interleukin-27 signaling (R-HSA-9020956)
  IL-6-type cytokine receptor ligand interactions (R-HSA-6788467)

References

• [1] Role of cytokine receptor-like factor 1 in hepatic stellate cells and fibrosis. World J Hepatol. 2012 Dec 27;4(12):356-64.