Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6ZFQ4)

DTT Name	Rotamase B (PPIB)
Synonyms	SCYLP; S-cyclophilin; Peptidyl-prolyl cis-trans isomerase B; PPIase B; Cyclophilin B; CYPB; CYP-S1
Gene Name	PPIB
DTT Type	Successful target	[1]
BioChemical Class	Cis-trans-isomerase
UniProt ID	PPIB_HUMAN
TTD ID	T25847
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 5.2.1.8
Sequence	MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRV IFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYG ERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVR KVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
Function	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
Reactome Pathway	Collagen biosynthesis and modifying enzymes (R-HSA-1650814 )
BioCyc Pathway	MetaCyc:HS09452-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Proline	DMKSTWR	Malnutrition	5B50-5B71	Approved	[1]
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1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,4-Dithiothreitol	DMIFOXE	Discovery agent	N.A.	Investigative	[2]
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References

1	Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer. Eur J Biochem. 2004 Sep;271(18):3794-803.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.