General Information of Drug Therapeutic Target (DTT) (ID: TT716MY)

DTT Name S100 calcium-binding protein A6 (S100A6)
Synonyms Protein S100-A6; Prolactin receptor-associated protein; PRA; MLN 4; Growth factor-inducible protein 2A9; Calcyclin; CACY
Gene Name S100A6
DTT Type
Literature-reported target
[1]
BioChemical Class
S100 calcium-binding protein
UniProt ID
S10A6_HUMAN
TTD ID
T68513
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDL
DRNKDQEVNFQEYVTFLGALALIYNEALKG
Function
May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. May function as calcium sensor and modulator, contributing to cellular calcium signaling.

References

1 Increased expression of S100A6 promotes cell proliferation in gastric cancer cells. Oncol Lett. 2017 Jan;13(1):222-230.