Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT71P0H)

DTT Name Cyclic nucleotide phosphodiesterase (CNP)
Synonyms CNPase; CNP; 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Gene Name CNP
DTT Type
Literature-reported target
 [1]
BioChemical Class
Phosphoric diester hydrolase
UniProt ID
CN37_HUMAN
TTD ID
T51464
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.1.4.37
Sequence
MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLLECKTLFILRGLPG
SGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILV
LDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPG
LEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRQFVPGDEPREKMDLVT
YFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARV
ELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSR
GEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGKGKPVPTQGSRKGGALQSCTI
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Function May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.

References

1 T cell response to 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in multiple sclerosis patients. J Neuroimmunol. 2002 Sep;130(1-2):233-42.