Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT71Q5Y)

DTT Name	Osteoclast-associated receptor (OSCAR)
Synonyms	hOSCAR; Polymeric immunoglobulin receptor 3; PolyIg receptor 3; PIgR3; Osteoclastassociated immunoglobulinlike receptor; OSCAR
Gene Name	OSCAR
DTT Type	Literature-reported target	[1]
BioChemical Class	Leukocyte receptor complex
UniProt ID	OSCAR_HUMAN
TTD ID	T81903
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MALVLILQLLTLWPLCHTDITPSVPPASYHPKPWLGAQPATVVTPGVNVTLRCRAPQPAW RFGLFKPGEIAPLLFRDVSSELAEFFLEEVTPAQGGIYRCCYRRPDWGPGVWSQPSDVLE LLVTEELPRPSLVALPGPVVGPGANVSLRCAGRLRNMSFVLYREGVAAPLQYRHSAQPWA DFTLLGARAPGTYSCYYHTPSAPYVLSQRSEVLVISWEGEGPEARPASSAPGMQAPGPPP SDPGAQAPSLSSFRPRGLVLQPLLPQTQDSWDPAPPPSDPGV
Function	Regulator of osteoclastogenesis which plays an importantbone-specific function in osteoclast differentiation.
KEGG Pathway	Osteoclast differentiation (hsa04380 )
Reactome Pathway	Neutrophil degranulation (R-HSA-6798695 ) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (R-HSA-198933 )

References

1	Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial Tissues of Patients with Active RA and TNF- and RANKL Regulation of Expression... Inflammation. 2017 Oct;40(5):1566-1575.