General Information of Drug Therapeutic Target (DTT) (ID: TT72D4Z)

DTT Name Recombining binding protein suppressor of hairless (RBPJ)
Synonyms Renal carcinoma antigen NY-REN-30; RBPSUH; RBPJK; RBP-JK; RBP-J kappa; RBP-J; J kappa-recombination signal-binding protein; IGKJRB1; IGKJRB; CBF-1
Gene Name RBPJ
DTT Type
Literature-reported target
[1]
UniProt ID
SUH_HUMAN
TTD ID
T04827
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDHTEGSPAEEPPAHAPSPGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSY
GNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGK
NYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLC
IASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDG
YIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCL
SQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESL
QLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQ
PVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPPNESNTNSEGS
YTNASTNSTSVTSSTATVVS
Function
Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits. Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations.
KEGG Pathway
Notch signaling pathway (hsa04330 )
Th1 and Th2 cell differentiation (hsa04658 )
Spinocerebellar ataxia (hsa05017 )
Human papillomavirus infection (hsa05165 )
Epstein-Barr virus infection (hsa05169 )
Viral carcinogenesis (hsa05203 )
Reactome Pathway
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (R-HSA-210744 )
NOTCH1 Intracellular Domain Regulates Transcription (R-HSA-2122947 )
NOTCH2 intracellular domain regulates transcription (R-HSA-2197563 )
Constitutive Signaling by NOTCH1 PEST Domain Mutants (R-HSA-2644606 )
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862 )
Notch-HLH transcription pathway (R-HSA-350054 )
RUNX3 regulates NOTCH signaling (R-HSA-8941856 )
NOTCH3 Intracellular Domain Regulates Transcription (R-HSA-9013508 )
NOTCH4 Intracellular Domain Regulates Transcription (R-HSA-9013695 )
Pre-NOTCH Transcription and Translation (R-HSA-1912408 )

References

1 RBPJ and MAML3: Potential Therapeutic Targets for Small Cell Lung Cancer. Anticancer Res. 2018 Aug;38(8):4543-4547.