Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT76B3W)

DTT Name Amphiregulin (AREG)
Synonyms SDGF; Colorectum cellderived growth factor; Colorectum cell-derived growth factor; CRDGF; AREGB; AR
Gene Name AREG
DTT Type
Literature-reported target
 [1]
UniProt ID
AREG_HUMAN
TTD ID
T92834
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG
SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT
SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER
CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK
LRQENGNVHAIA
Function Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Ligand of the EGF receptor/EGFR.
KEGG Pathway
MAPK signaling pathway (hsa04010 )
ErbB signaling pathway (hsa04012 )
PI3K-Akt signaling pathway (hsa04151 )
Hippo signaling pathway (hsa04390 )
Colorectal cancer (hsa05210 )
Reactome Pathway
Signaling by EGFR (R-HSA-177929 )
GRB2 events in EGFR signaling (R-HSA-179812 )
GAB1 signalosome (R-HSA-180292 )
SHC1 events in EGFR signaling (R-HSA-180336 )
EGFR downregulation (R-HSA-182971 )
COPII-mediated vesicle transport (R-HSA-204005 )
EGFR interacts with phospholipase C-gamma (R-HSA-212718 )
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530 )
Inhibition of Signaling by Overexpressed EGFR (R-HSA-5638303 )
RAF/MAP kinase cascade (R-HSA-5673001 )
Cargo concentration in the ER (R-HSA-5694530 )
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (R-HSA-6811558 )
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825 )
Clathrin-mediated endocytosis (R-HSA-8856828 )
Extra-nuclear estrogen signaling (R-HSA-9009391 )
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (R-HSA-9634638 )
PIP3 activates AKT signaling (R-HSA-1257604 )

References

1 Amphiregulin as a novel target for breast cancer therapy. J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):171-9.